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Contraindicated (1)nirmatrelvir/ritonavir will boost the stage or influence of triazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism.rufinamide will decrease the extent or influence of triazolam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.Coadministration of encorafenib with delicate CYP3A4 substrates co